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About The Eye Birth Defects Institute

The Eye Birth Defects Institute in the Vision Center at Childrens Hospital Los Angeles treats and studies congenital diseases that result in anatomic abnormalities of the eye and optic nerve. Under the direction of Mark Borchert, MD, we are the leading research center in the epidemiology and management of Optic Nerve Hypoplasia (ONH) and other devastating birth defects, including other optic nerve disorders, colobomas, morning glory syndrome, ophthalmic cysts, aniridia, and more.

ONH occurs when a child’s optic nerves fail to develop fully during early pregnancy, resulting in reduced vision or blindness. ONH is now the foremost single cause of blindness and visual impairment in infants in the United States. The Eye Birth Defects Institute has the largest study in the world on ONH, with more than 200 subjects enrolled in an ongoing prospective study to determine the prenatal and clinical risk factors for adverse outcomes in children.

The Eye Birth Defects Institute is part of the Vision Center at Childrens Hospital Los Angeles, one of the hospital’s Centers of Excellence. Other components of the Vision Center are: